| | J.W. Eagan | | | 0000 | |
| | Thomas Eagleton | Politician | US Senator from Missouri, 1969-87 | 1929 | 2007 |
| | Amelia Earhart | Aviator | Misplaced aviatrix | 1897 | 1937 |
| | Steve Earle | Singer/Songwriter | Copperhead Road | 1955 | |
| | Gerald Early | Essayist | American culture critic | 1952 | |
| | Dale Earnhardt | Auto Racing | | 1951 | 2001 |
| | Wyatt Earp | Government | Gunfight at the O.K. Corral | 1848 | 1929 |
| | George Eastman | Inventor | Inventor of the Kodak camera | 1854 | 1932 |
| | Max Eastman | Author | Socialist writer, later embraced McCarthyism | 1883 | 1969 |
| | Clint Eastwood | Actor | Dirty Harry | 1930 | |
| | Eazy-E | Rapper | N.W.A. member | 1963 | 1995 |
| | Abba Eban | Government | Foreign Minister of Israel, 1966-74 | 1915 | 2002 |
| | Fred Ebb | Songwriter | Ebb, Fred | 1933 | 2004 |
| | Petr Eben | Composer | Czech composer | 1929 | 2007 |
| | Richard Eberhart | Poet | Collected Poems | 1904 | 2005 |
| | Johann Ernst Eberlin | Composer | German composer and organist | 1702 | 1762 |
| | Roger Ebert | Critic | | 1942 | |
| | Marie von Ebner-Eschenbach | Novelist | German-language author | 1830 | 1916 |
| | Buddy Ebsen | Actor | Jed Clampett | 1908 | 2003 |
| | Johann Eccard | Composer | | 1553 | 1611 |
| | Henry Eccles | Composer | | 1675 | 1742 |
| | John Eccles | Composer | | 1668 | 1735 |
| | Meister Eckhart | Religion | German speculative mystic | 1260 | 1328 |
| | Billy Eckstine | Singer | First African-American singing idol | 1914 | 1993 |
| | Umberto Eco | Author | The Name of the Rose | 1932 | |
| | Arthur Eddington | Astronomer | Early astrophysicist | 1882 | 1944 |
| | Paul Eddington | Actor | Jim Hacker on Yes, Prime Minister | 1927 | 1992 |
| | Duane Eddy | Guitarist | | 1938 | |
| | Mary Baker Eddy | Religion | Founder of Christian Science | 1821 | 1910 |
| | Nelson Eddy | Actor | | 1901 | 1967 |
| | Leon Edel | Author | Biographer of Henry James | 1907 | 1997 |
| | Herb Edelman | Actor | Stan Zbornak on The Golden Girls | 1933 | 1996 |
| | Marian Wright Edelman | Activist | Founder, Children's Defense Fund | 1939 | |
| | Anthony Eden | Head of State | UK Prime Minister, 1955-57 | 1897 | 1977 |
| | Barbara Eden | Actor | I Dream of Jeannie | 1934 | |
| | The Edge | Guitarist | Guitarist for U2 | 1961 | |
| | Maria Edgeworth | Author | Castle Rackrent | 1767 | 1849 |
| | Thomas A. Edison | Inventor | Invented the light bulb | 1847 | 1931 |
| | Dave Edmunds | Musician | I Hear You Knocking | 1944 | |
| | Bob Edwards | Journalist | NPR's Morning Edition host, 1979-2004 | 1947 | |
| | Cliff Edwards | Musician | | 1895 | 1971 |
| | Gus Edwards | Songwriter | In My Merry Oldsmobile | 1879 | 1945 |
| | John Edwards | Politician | 2004 Vice Presidential candidate | 1953 | |
| | Jonathan Edwards | Religion | American Puritan theologian | 1703 | 1758 |
| | Ross Edwards | Composer | Australian composer | 1943 | |
| | Tryon Edwards | Author | New Dictionary of Thoughts | 1809 | 1894 |
| | Edwin Lutyens | Architect | | 1869 | 1944 |
| | Zac Efron | Actor | Cameron Bale on Summerland | 1987 | |
| | Walter Egan | Musician | Magnet and Steel | 1948 | |
| | Werner Egk | Composer | | 1901 | 1983 |
| | Jennifer Ehle | Actor | Sunshine | 1969 | |
| | Barbara Ehrenreich | Author | Nickel and Dimed | 1941 | |
| | Paul Ehrlich | Doctor | Chemotherapy | 1854 | 1915 |
| | Sixten Ehrling | Conductor | | 1918 | 2005 |
| | Kurt Eichhorn | Conductor | German conductor | 1908 | 1994 |
| | Adolph Eichmann | Criminal | Nazi war criminal | 1906 | 1962 |
| | Manfred Eigen | Physicist | | 1927 | |
| | Sally Eilers | Actor | Coroner Creek | 1908 | 1978 |
| | Gottfried von Einem | Composer | Der Besuch der alten Dame | 1918 | 1996 |
| | Albert Einstein | Physicist | Theory of relativity | 1879 | 1955 |
| | Loren Eiseley | Anthropologist | The Firmament of Time | 1907 | 1977 |
| | Dwight D. Eisenhower | President | 34th US President, 1953-61 | 1890 | 1969 |
| | Mamie Eisenhower | First Lady | Ike's First Lady | 1896 | 1979 |
| | Alfred Eisenstaedt | Photographer | Life magazine photographer | 1898 | 1995 |
| | Sergei Eisenstein | Film Director | Alexander Nevsky | 1898 | 1948 |
| | Hans Eisler | Composer | | 1898 | 1962 |
| | Britt Ekland | Actor | The Man with the Golden Gun | 1942 | |
| | Jack Elam | Actor | The Sundowners | 1918 | 2003 |
| | C. Burke Elbrick | Diplomat | Career US Ambassador | 1908 | 1983 |
| | Dana Elcar | Actor | Pete Thornton on MacGyver | 1927 | 2005 |
| | Joycelyn Elders | Government | Surgeon General | 1933 | |
| | Paul Eldridge | Poet | My First Two Thousand Years | 1888 | 1982 |
| | Roy Eldridge | Jazz Musician | American jazz trumpet player | 1911 | 1989 |
| | Carmen Electra | Model | Singled Out | 1972 | |
| | Danny Elfman | Film/TV Music Composer | Oingo Boingo | 1953 | |
| | Edward Elgar | Composer | Pomp and Circumstance | 1857 | 1934 |
| | Gertrude B. Elion | Scientist | Developed medicines for leukemia, herpes, AIDS | 1918 | 1999 |
| | Alexander Eliot | Author | Three Hundred Years of American Painting | 1919 | |
| | George Eliot | Novelist | Silas Marner | 1819 | 1880 |
| | T. S. Eliot | Poet | The Hollow Men | 1888 | 1965 |
| | Elizabeth I of England | Royalty | Queen of England | 1533 | 1603 |
| | Elizabeth II | Royalty | Queen of England | 1926 | |
| | Shannon Elizabeth | Actor | Nadia in American Pie 1 and 2 | 0000 | |
| | Heino Eller | Composer | | 1887 | 1970 |
| | Linda Ellerbee | Journalist | And so it goes. | 1944 | |
| | Martin Ellerby | Composer | English composer | 1957 | |
| | Duke Ellington | Jazz Musician | It Don't Mean a Thing, If It Ain't Got That Swing | 1899 | 1974 |
| | Cass Elliot | Musician | The Mamas and the Papas | 1941 | 1974 |
| | Chris Elliott | Comic | The David Letterman Show | 1960 | |
| | Denholm Elliott | Actor | A Room with a View | 1922 | 1992 |
| | Joe Elliott | Musician | Def Leppard vocalist | 1959 | |
| | Missy Elliott | Rapper | Get Ur Freak On | 1971 | |
| | Ross Elliott | Actor | American television and film character actor | 1917 | 1999 |
| | Sam Elliott | Actor | Mission: Impossible | 1944 | |
| | Albert Ellis | Psychologist | Rational emotive behavior therapy | 1913 | 2007 |
| | Havelock Ellis | Biologist | Studies in the Psychology of Sex | 1859 | 1939 |
| | Henry Ellis | Educator | English librarian | 1777 | 1869 |
| | W. T. Ellis | Business | Western Pacific Railroad purchasing agent | 1866 | 9999 |
| | Harlan Ellison | Author | I Have No Mouth And I Must Scream | 1934 | |
| | Larry Ellison | Business | CEO of Oracle | 1944 | |
| | Ralph Ellison | Author | | 1913 | 1994 |
| | George Job Elvey | Composer | | 1816 | 1893 |
| | Rahm Emanuel | Politician | Congressman, Illinois 5th | 1959 | |
| | Keith Emerson | Musician | Keyboardist for Emerson, Lake, and Palmer | 1944 | |
| | Ralph Waldo Emerson | Poet | Essayist, wrote Nature | 1803 | 1882 |
| | Eminem | Rapper | The Real Slim Shady | 1972 | |
| | Daniel Emmett | Songwriter | Dixie | 1815 | 1904 |
| | Emperor Wen of Sui | Royalty | First emperor of China's Sui Dynasty | 0541 | 0604 |
| | Juan del Encina | Playwright | Founder of Spanish drama | 1469 | 1529 |
| | Georges Enescu | Composer | Romanian Rhapsody No. 1 | 1881 | 1955 |
| | Lehman Engel | Composer | Conducted many Broadway musicals | 1910 | 1982 |
| | Friedrich Engels | Philosopher | Communist Manifesto | 1820 | 1895 |
| | Paul Engle | Author | Iowa Writers' Workshop (1941-1965) | 1908 | 1991 |
| | Sven Einar Englund | Composer | | 1916 | 1999 |
| | Brian Eno | Music Producer | Father of ambient music | 1948 | |
| | John Entwistle | Bassist | The Who | 1944 | 2002 |
| | Peg Entwistle | Actor | Starlet, suicided off Hollywood sign | 1908 | 1932 |
| | Peter Eötvös | Composer | Hungarian composer and conductor | 1944 | |
| | Nora Ephron | Author | When Harry Met Sally | 1941 | |
| | Epictetus | Philosopher | Stoic, wrote Encheiridion | 0055 | 0135 |
| | Epicurus | Philosopher | Founder of the Epicurean School | 0341 BC | 0270 BC |
| | Brian Epstein | Business | Manager of The Beatles | 1934 | 1967 |
| | Howie Epstein | Musician | Tom Petty and the Heartbreakers. | 1955 | 2003 |
| | Erasmus | Religion | In Praise of Folly | 1466 | 1536 |
| | Donald Erb | Composer | Klangfarbenfunk | 1927 | 2008 |
| | Christian Erbach | Composer | German organist and composer | 1568 | 1635 |
| | Paul Erdman | Economist | The Billion Dollar Sure Thing | 1932 | 2007 |
| | Recep Tayyip Erdogan | Head of State | Prime Minister of Turkey 2003- | 1954 | |
| | Paul Erdos | Mathematician | Founded the field of discrete mathematics | 1913 | 1996 |
| | Louise Erdrich | Novelist | Love Medicine | 1954 | |
| | Werner Erhard | Religion | Erhard Seminar Training ("est") | 1935 | |
| | Leif Erickson | Actor | The High Chaparral | 1911 | 1986 |
| | Ferenc Erkel | Composer | "Himnusz", the national anthem of Hungary | 1810 | 1893 |
| | Heinrich Wilhelm Ernst | Composer | | 1814 | 1865 |
| | John Erskine | Author | Founder of Columbia University’s core curriculum | 1879 | 1951 |
| | Sam Ervin | Politician | US Senator from North Carolina, 1954-74 | 1896 | 1985 |
| | Evan Esar | Author | 20,000 Quips and Quotes | 1899 | 1995 |
| | M.C. Escher | Artist | Mathematically inspired woodcuts | 1898 | 1972 |
| | Rudolf Escher | Composer | Dutch composer | 1912 | 1980 |
| | Pedro de Escobar | Composer | Portuguese composer of the Renaissance | 1465 | 1535 |
| | Oscar Esplá | Composer | Levantine Impressions | 1886 | 1976 |
| | David Essex | Actor | | 1947 | |
| | Gloria Estefan | Singer/Songwriter | The Miami Sound Machine | 1957 | |
| | Emilio Estevez | Actor | Otto in Repo Man | 1962 | |
| | Alvin Etler | Composer | American composer and oboist | 1913 | 1973 |
| | Ruth Etting | Singer | Shine on Harvest Moon | 1895 | 1978 |
| | Euclid of Alexandria | Mathematician | The Elements | 0365 BC | 0275 BC |
| | Leonhard Euler | Mathematician | The Elements of Euclid | 1707 | 1783 |
| | Euripides | Playwright | Medea | 0480 BC | 0406 BC |
| | Linda Evangelista | Model | Won't wake up for less than $10K/day | 1965 | |
| | Bill Evans | Jazz Musician | Jazz pianist | 1929 | 1980 |
| | Bob Evans | Business | Founder of the Bob Evans Restaurants | 1918 | 2007 |
| | Dale Evans | Actor | Singer and leading lady to Roy Rogers | 1912 | 2001 |
| | Edith Evans | Actor | The Whisperers | 1888 | 1976 |
| | Faith Evans | Singer/Songwriter | Notorious B.I.G.'s widow | 1973 | |
| | Mike Evans | Actor | Lionel Jefferson on The Jeffersons | 1949 | 2006 |
| | Ray Evans | Songwriter | Buttons and Bows | 1915 | 2007 |
| | John Evelyn | Author | English diarist | 1620 | 1706 |
| | Edward Everett | Politician | | 1794 | 1865 |
| | Don Everly | Musician | The Everly Brothers | 1937 | |
| | Chris Evert | Tennis | The Ice Maiden | 1954 | |
| | Victor Ewald | Composer | Brass Quintets | 1860 | 1935 |
| | Eric Ewazen | Composer | | 1954 | |
| | Patrick Ewing | Basketball | New York Knicks | 1962 | |
| | Sam Ewing | Author | Free lance writer | 1920 | 2001 |
| | Gnassingbe Eyadema | Head of State | Dictator of Togo 1967-2005 | 1937 | 2005 |
| | Joseph Eybler | Composer | Friendship with Mozart | 1765 | 1846 |