| | Lee Iacocca | Business | Former chairman, Chrysler Corporation | 1924 | |
| | Jacques Ibert | Composer | Escales | 1890 | 1962 |
| | Henrik Ibsen | Playwright | Peer Gynt | 1828 | 1906 |
| | Ice Cube | Musician | N.W.A., Boyz N the Hood | 1969 | |
| | Toshi Ichiyanagi | Composer | Kaiki | 1993 | |
| | Harold L. Ickes | Government | US Secretary of the Interior, 1933-46 | 1874 | 1952 |
| | Eric Idle | Actor | | 1942 | |
| | Billy Idol | Musician | Punk rocker | 1955 | |
| | Julio Iglesias | Singer | International pop star | 1943 | |
| | Ignatius of Loyola | Religion | Founder of the Jesuit order | 1491 | 1556 |
| | Natalie Imbruglia | Singer/Songwriter | Torn | 1975 | |
| | Pete Incaviglia | Baseball | Major League Baseball outfielder | 1964 | |
| | William Ralph Inge | Author | Evening Standard columnist | 1860 | 1954 |
| | Marc Antonio Ingegneri | Composer | Teacher of Claudio Monteverdi | 1547 | 1592 |
| | Jean Ingelow | Poet | High Tide on the Coast of Lincolnshire | 1829 | 1897 |
| | Robert Ingersoll | Author | Orator, politician, agnostic | 1833 | 1889 |
| | Bob Inglis | Politician | Congressman, South Carolina | 1959 | |
| | Rex Ingram | Actor | The Talk of the Town | 1895 | 1969 |
| | John Inman | Actor | Are You Being Served? | 1935 | 2007 |
| | Laura Innes | Actor | Dr. Kerry Weaver on ER | 1957 | |
| | Neil Innes | Musician | The Rutles | 1944 | |
| | Daniel Inouye | Politician | US Senator from Hawaii | 1924 | |
| | Mikhail Ippolitov-Ivanov | Composer | Caucasian Sketches | 1859 | 1935 |
| | Sebastián Iradier | Composer | El Arreglito, Habanera" from Carmen | 1809 | 1865 |
| | John Ireland | Composer | The Holy Boy | 1879 | 1962 |
| | Kathy Ireland | Model | 1989 Sports Illustrated Swimsuit Issue | 1963 | |
| | Jack Irons | Drummer | | 1962 | |
| | Jeremy Irons | Actor | Dead Ringers | 1948 | |
| | Amy Irving | Actor | Carrie and Yentl | 1953 | |
| | Clifford Irving | Hoaxer | Howard Hughes autobiography hoax | 1930 | |
| | John Irving | Novelist | The World According to Garp | 1942 | |
| | Washington Irving | Author | Legend of Sleepy Hollow | 1783 | 1859 |
| | May Irwin | Actor | Major star of vaudeville | 1862 | 1938 |
| | Steve Irwin | Naturalist | The Crocodile Hunter | 1962 | 2006 |
| | Wallace Irwin | Author | Rhyme of the Chivalrous Shark | 1875 | 1959 |
| | Heinrich Isaac | Composer | | 1450 | 1517 |
| | Chris Isaak | Musician | The Chris Isaak Show | 1956 | |
| | Isabella I of Castile | Royalty | Bankrolled Columbus, persecuted Jews | 1451 | 1504 |
| | Christopher Isherwood | Author | Goodbye to Berlin, I Am a Camera | 1904 | 1986 |
| | Rudolf Ising | Cartoonist | Co-creator of Looney Tunes and Merrie Melodies | 1903 | 1992 |
| | Eugene Istomin | Pianist | Premiered Roger Sessions' Piano Concerto | 1925 | 2003 |
| | Jose Iturbi | Conductor | Anchors Aweigh, | 1895 | 1980 |
| | Ivan IV | Royalty | Russian Tsar, 1533-84 | 1530 | 1584 |
| | Burl Ives | Musician | | 1909 | 1995 |
| | Charles Ives | Composer | Symphony No. 3 (The Camp Meeting) | 1874 | 1954 |
| | Molly Ivins | Columnist | Political commentator | 1944 | 2007 |
| | Ivy Queen | Rapper | Queen of Reggaeton | 1972 | |
| | Eddie Izzard | Comic | Dress to Kill | 1962 | |